Incorporation into a biodegradable hyaluronic acid matrix enhances in vivo efficacy of recombinant human interleukin 11 (rhIL11)

In order to improve the therapeutic efficacy of recombinant human interleukin 11 and to reduce its frequency of administration, the feasibility of a sustained release formulation consisting of hyaluronic acid was investigated. rhIL11 was mixed together with an aqueous solution of HyA or HyA and protamine, and the mixture was lyophilized

Akira Takagi

2006

Scholarcy highlights

  • In order to improve the therapeutic efficacy of recombinant human interleukin 11 and to reduce its frequency of administration, the feasibility of a sustained release formulation consisting of hyaluronic acid was investigated. rhIL11 was mixed together with an aqueous solution of HyA or HyA and protamine, and the mixture was lyophilized
  • The plasma profile of rhIL11 was determined by ELISA
  • The mean residence time and tmax of rhIL11 were much prolonged by administration in an HyA pellet
  • The degree of platelet increase in rats treated with the pellets was comparable to that for rats treated with 1- or 2-day continuous infusion from an osmotic mini-pump; these data reflect the importance of increased plasma duration of rhIL11
  • These data indicate that use of hyaluronic acid as a polymer matrix might enhance the therapeutic efficacy of rhIL11
  • These data indicate that use of hyaluronic acid as a polymer matrix might enhance the therapeutic efficacy of recombinant human interleukin 11

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