Toward a major risk factor for atopic eczema: Meta-analysis of filaggrin polymorphism data

For the combined genotype, we found an overall odds ratios of 4.09 from the case-control studies and a summary OR of 2.06 from the family studies

Hansjörg Baurecht

2007

Scholarcy highlights

  • With an impressive series of replication studies, filaggrin has become the gene with the most widely replicated association to atopic eczema
  • For the combined genotype, we found an overall odds ratios of 4.09 from the case-control studies and a summary OR of 2.06 from the family studies
  • The powerful effect of FLG variation on AE risk exceeds that of any other investigated candidate gene for AE far and makes FLG one of the strongest genes known to date for complex diseases
  • We focused on the association with AE because only few comparable studies are available far for related traits
  • Our comprehensive meta-analysis is based on an impressive series of replication studies that have followed the initial publication from Palmer et al Palmer C.N.A
  • The test of asymmetry showed no significant deviation from the symmetry assumption, not indicating any publication bias. For both null alleles, a strong overall FLG effect was calculated with an OR of 4.23 for R501X and 4.13 for 2282del4, respectively
  • Our analysis demonstrates that across all studies there is a high risk independently conferred by both null polymorphisms, with an estimated overall OR of 3.51, 3.62, and 3.58 for R501X, 2282del4, and the combined genotype, respectively
  • A rather homogeneous estimate of the FLG risk on atopic eczema could be observed for the family studies, possibly reflecting the known additional level of control for occult genetic admixture, which might confound case-control studies

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