Association between atopy and cryptorchidism

Testicular cancer has been shown to be associated with atopy, To further elucidate associations between atopy and testicular disorders, we prospectively examined 908 consecutive male patients aged 19 to 62 years attending our andrologic outpatient department because of unfulfilled desire for children

S Weidinger

2004

Scholarcy highlights

  • Epidemiologic studies have shown an increasing prevalence of both atopic diseases and disorders of male sexual differentiation such as cryptorchidism
  • Testicular cancer has been shown to be associated with atopy, To further elucidate associations between atopy and testicular disorders, we prospectively examined 908 consecutive male patients aged 19 to 62 years attending our andrologic outpatient department because of unfulfilled desire for children
  • Patients who reported a physician's diagnosis of asthma, recurrent spastic bronchitis, or recurrent asthmatic bronchitis as well as a history of asthmatic symptoms and the use of antiasthmatic medication were classified as having asthma
  • Atopic diseases show a strong variability in clinical parameters and disease course
  • Because the influence of environmental and lifestyle factors on the expression of atopy seems to be most important during gestation and early childhood, it may be hypothesized that next to genetic factors, environmental influences during pregnancy, like disturbance of the hormonal balance, might contribute to the development of both atopy and testicular disorders
  • It has been shown that relaxin and RLF are secreted by various other tissues and that relaxin is a multifunctional hormone not involved in reproduction only
  • The results of the current study indicate an association between atopy and testicular disorders, implying shared genetic or environmental factors

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