Distinct patterns of gene expression in the skin lesions of atopic dermatitis and psoriasis

These results show a very distinctive gene expression pattern in Atopic dermatitis as compared with psoriasis that may explain several features of AD and psoriasis including the specific inflammatory cell infiltrates observed in these disorders, that is, TH2 cells, eosinophils, and mast cells in AD and TH1 cells and neutrophils in psoriasis

Ichiro Nomura; Bifeng Gao; Mark Boguniewicz; Marc A. Darst; Jeffrey B. Travers; Donald Y.M. Leung

2003

Scholarcy highlights

  • Atopic dermatitis and psoriasis are the two most common chronic inflammatory skin diseases
  • These results show a very distinctive gene expression pattern in AD as compared with psoriasis that may explain several features of AD and psoriasis including the specific inflammatory cell infiltrates observed in these disorders, that is, TH2 cells, eosinophils, and mast cells in AD and TH1 cells and neutrophils in psoriasis
  • It is well established that both skin diseases are genetically inherited and mediated by immunologic processes, the exact mechanisms leading to skin inflammation are poorly understood
  • AD skin lesions are characterized by intensely pruritic erythematous papules associated with epidermal intercellular edema as well as increased numbers of IgE-bearing Langerhans cells, inflammatory dendritic epidermal cells, macrophages, eosinophils, and CD4-activated TH2 cells
  • Presence of high contents of thymus and activation-regulated chemokine in platelets and elevated plasma levels of thymus and activation-regulated chemokine and macrophage-derived chemokine in patients with atopic dermatitis
  • Genes called “increase” or “decrease” in more than 70% of comparisons and at least a 2-fold change were picked and grouped for statistical tests
  • In AD skin lesions, we found a remarkable increase in the expression of a group of genes encoding CC chemokines, which are known to attract TH2 cells and eosinophils, whereas psoriasis was associated with increased expression of CXC chemokines, which are known to attract TH1 cells and neutrophils
  • Atopic dermatitis skin lesions are characterized by intensely pruritic erythematous papules associated with epidermal intercellular edema as well as increased numbers of IgE-bearing Langerhans cells, inflammatory dendritic epidermal cells, macrophages, eosinophils, and CD4-activated TH2 cells

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