Chitosan-dibasic orthophosphate hydrogel: A potential drug delivery system

Injectable thermo-activated hydrogels have shown great potential in biomedical applications including use in therapeutic delivery vehicles. In addition to their biocompatibility, the feasibility of these delivery systems is significantly contributed by their ability to gel at physiological conditions and to release entrapped molecules in a sustained manner

Hang T. Ta

2009

Scholarcy highlights

  • Injectable thermo-activated hydrogels have shown great potential in biomedical applications including use in therapeutic delivery vehicles. In addition to their biocompatibility, the feasibility of these delivery systems is significantly contributed by their ability to gel at physiological conditions and to release entrapped molecules in a sustained manner
  • Monobasic and tribasic phosphate salts were not effective in inducing gelation of chitosan solution
  • The release rate of the entrapped macromolecules depended on chitosan concentration, dipotassium hydrogen orthophosphate concentration, structural conformation and molecular weight of entrapped agents
  • Chitosan/DHO hydrogels were found to be cytocompatible as evaluated in an in vitro study using a human cell line. These results indicate the potential of Chi/DHO hydrogels as delivery systems for different therapeutic agents with controlled release kinetics
  • These results indicate the potential of Chi/dipotassium hydrogen orthophosphate hydrogels as delivery systems for different therapeutic agents with controlled release kinetics

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