The effect of solubilization on the oral bioavailability of three benzimidazole carbamate drugs

The effect of solubilization by complexation with povidone on the oral bioavailability of three anthelmintic benzimidazole carbamate drugs: mebendazole, albendazole and ricobendazole, was studied in mice

K Daniel-Mwambete

2004

Scholarcy highlights

  • The effect of solubilization by complexation with povidone on the oral bioavailability of three anthelmintic benzimidazole carbamate drugs: mebendazole, albendazole and ricobendazole, was studied in mice
  • For the in vivo parameters related to the amount of absorbed drug, the best correlation was obtained with the in vitro characteristics related to solubility which are Cs, melting point and mean dissolution time
  • There were good linear correlations between Tmax which is an in vivo parameter related to the rate of drug absorption, and the lipophilia/hydrophilia relation-parameters

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