Ontogeny of the immune system of fish

We review these three main topics with special emphasis on recent results obtained from the zebrafish, a new experimental model suitable for study of the ontogeny of the immune system because of its rapid development and easy manipulation

A. Zapata; B. Diez; T. Cejalvo; C. Gutiérrez-de Frías; A. Cortés

2005

Scholarcy highlights

  • Information on the ontogeny of the fish immune system is largely restricted to a few species of teleosts and has previously focused on morphological features
  • Basic questions including the identification of the first lympho-hematopoietic sites, the origin of T- and B-lymphocytes and the acquisition of full immunological capacities remain to be resolved
  • We review these three main topics with special emphasis on recent results obtained from the zebrafish, a new experimental model suitable for study of the ontogeny of the immune system because of its rapid development and easy manipulation
  • In some teleosts the first blood cells are formed in the yolk sac. In others, such as zebrafish, the first hematopoietic site is an intraembryonic locus, the intermediate cell mass, whereas in both killifish and rainbow trout the first blood cells appear for a short time in the yolk sac but later the ICM becomes the main hematopoietic area
  • The origins and time of appearance of B lymphocytes in teleosts are a matter of discussion and recent results are summarized here
  • The main characteristics of some of these mutants will be described

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