Solvent-free protamine nanocapsules as carriers for mucosal delivery of therapeutics

A protamine-based nanosystem is proposed as a carrier for mucosal delivery of therapeutics

Paulina Jakubiak

2017

Scholarcy highlights

  • A protamine-based nanosystem is proposed as a carrier for mucosal delivery of therapeutics
  • Protamine nanocapsules with a new composition were for the first time prepared by a self-emulsifying process, without the use of organic solvents or heat
  • The CsA-loaded formulation was isolated from the free drug by gel filtration and the entrapment efficiency was determined using reverse phase high-performance liquid chromatography
  • In vitro studies performed with the Jurkat human T lymphocyte cell line showed that CsA-loaded protamine nanocapsules are more efficient than the commercial Sandimmune Neoral® formulation at reducing IL-2 secretion (γγp

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