Interleukin-12 p40 promoter activity is regulated by the reversible acetylation mediated by HDAC1 and p300

We showed that p300 had a physical interaction with C/EBPβ and can enhance acetylation of C/EBPβ

Jun Lu; Haijing Sun; Xiuli Wang; Chunyan Liu; Xin Xu; Fen Li; Baiqu Huang

2005

Scholarcy highlights

  • Interleukin-12 is a heterodimeric cytokine produced by macrophages in response to intracellular pathogens
  • Whether the reversible histone acetylation/deacetylation modification participates in the regulation of IL-12 p40 transcription expression has not been investigated before
  • We analyzed the roles of HDAC1 and p300 in the regulation of human IL-12 p40
  • Co-transfection studies showed that HDAC1 had a repressing effect on the activity of IL-12 p40 promoter
  • Data presented in this paper indicate that the reversible histone acetylation/deacetylation modification plays an important role in the transcriptional regulation of IL-12

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