Acute and chronic effects of clofibrate and clofibric acid on the enzymes acetylcholinesterase, lactate dehydrogenase and catalase of the mosquitofish, Gambusia holbrooki

The objective of this study was to investigate both acute and chronic effects of clofibrate and clofibric acid on the enzymes acetylcholinesterase, lactate dehydrogenase and catalase of the mosquitofish

B. Nunes; F. Carvalho; L. Guilhermino

2004

Scholarcy highlights

  • The objective of this study was to investigate both acute and chronic effects of clofibrate and clofibric acid on the enzymes acetylcholinesterase, lactate dehydrogenase and catalase of the mosquitofish
  • LDH, an important enzyme of anaerobic metabolism, was quantified in dorsal muscle, and CAT, enzyme which has been used as indicative parameter of peroxisome proliferation, was determined in the liver
  • Acute exposure of G. holbrooki to both clofibrate and clofibric acid induced a decrease in liver CAT activity, an increase in muscle LDH activity, while no effects were observed on AChE activity
  • FĂ©lix Dias Carvalho, Ph.D., Auxiliar Professor at the Faculty of Pharmacy, University of Porto, where he is a lecturer of Ecotoxicology since 1998
  • His research is related with the evaluation of molecular mechanisms, both in basic toxicology and in ecotoxicology
  • Head of the Group of Ecotoxicology of the Centre of Marine and Environmental Research

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