Novel angiogenic metal nanoparticles controlling intracellular gene activation in stem cells

New concept for metal ion exocytosis and its effect with ADSCs in ischemic disease were covered

Gwang-Bum Im; Jaeyoung Lee; Jiwoo Song; Taekyung Yu; Suk Ho Bhang

2021

Scholarcy highlights

  • New concept for metal ion exocytosis and its effect with ADSCs in ischemic disease were covered
  • Cu-based angiogenic metal nanoparticles were significantly improved in oxidation, cytotoxicity, and biodegradation
  • Mechanism of intercellular Cu-AMNs on human cells was investigated for the first time
  • Transplantation of Cu-AMN-treated human adipose-derived stem cells in mice led to a significant in vivo increase in angiogenesis and blood perfusion in a mouse hindlimb ischemia model compared with conventional hADSC therapy
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