Polyelectrolyte complexes of gum kondagogu and chitosan were prepared by mixing polymeric solutions of different concentrations
2008
Key concepts
Scholarcy highlights
- Polyelectrolyte complexes of gum kondagogu and chitosan were prepared by mixing polymeric solutions of different concentrations
- The complex formed were loaded with diclofenac sodium, and the release of the drug was measured invitro and in vivo, along with the measurement of particle size, zeta potential, complex formation, flow properties, and loading efficiency
- Maximum yield of PEC was observed at gum kondagogu concentrations above 80%
- PEC 1:3 with higher concentration of chitosan showed 98% release with in 4.5 h, owing to the fact that chitosan has a higher degree of swelling in acidic medium
- PEC 5:1 and 3:1 showed a 5.3- and 5.8-fold increase in relative bioavailability compared to the free drug when administered orally to the rats
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