Microfabrication of poly (glycerol–sebacate) for contact guidance applications

This study investigates several strategies to advance contact guidance strategies and technology to more practical applications

Christopher J. Bettinger


Scholarcy highlights

  • Extracellular matrix proteins are known to contain a rich three-dimensional surface topography that presents biophysical cues to cells
  • Controlling cell orientation and morphology through topographical patterning is a phenomenon that is applicable to a wide variety of medical applications such as implants and tissue engineering scaffolds
  • Demonstrating contact guidance and topography in a biodegradable material platform is a promising strategy for controlling cellular arrangements in tissue engineering scaffolds
  • Contact guidance has been shown to induce a variety of cellular responses such as the up regulation of fibronectin mRNA in human fibroblasts, increased adhesion of epithelial cells, and increased mineralization and alkaline phosphatase activity in rat bone marrow cells
  • Using bovine aortic endothelial cells as a model cell system, we studied the morphology of bAECs grown on substrates with periods of approximately 2.5 and 4.5 μm with constant feature height of 0.45 μm
  • The superior mechanical and biocompatibility properties of PGS coupled with the observed strong contact guidance responses of cells cultured on microfabricated PGS renders this system appropriate for in vivo applications
  • Poly(glycerol sebacate) has been proposed for tissue engineering applications owing to its tough elastomeric mechanical properties, biocompatibility and controllable degradation

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