Evaluation of an in situ forming hydrogel wound dressing based on oxidized alginate and gelatin

We describe such an in situ forming hydrogel wound dressing from gelatin, oxidized alginate and borax



Scholarcy highlights

  • Wound healing is a dynamic process and the performance requirements of a dressing can change as healing progresses
  • The composite matrix has the haemostatic effect of gelatin, the wound healing-promoting feature of alginate and the antiseptic property of borax to make it a potential wound dressing material
  • The wound healing efficacy of hydrogel was evaluated in experimental full thickness wounds using a rat model which demonstrated that within 2 weeks, the wound covered with gel was completely filled with new epithelium without any significant adverse reactions
  • We showed that the presence of small concentrations of borax accelerated the reaction between periodate-oxidized alginate and gelatin to give in situ forming hydrogels rapidly
  • A 20% solution of ADA having degree of oxidation 57% and a 15% solution of gelatin were optimal with respect to dissolution, ease of handling and gelation time in the preparation of hydrogels for many applications
  • The in situ forming wound dressing reported in this investigation employs a very simple method to prepare hydrogels that combines the beneficial properties of both alginate and gelatin and eliminates the use of extraneous cross-linking agents
  • The water vapour transmission rate and water absorptivity of the hydrogel were found to be highly optimal for maintaining a moist environment conducive for wound

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