Antimicrobial mechanism of flavonoids against Escherichia coli ATCC 25922 by model membrane study

This study provides a liposome model capable of mimicking the cell membrane of E. coli ATCC 25922

Mengying He

2014

Scholarcy highlights

  • The lipid model is proposed to study the antimicrobial mode of flavonoids
  • Antimicrobial mechanism of four flavonoids against Escherichia coli ATCC 25922 was investigated through cell membranes and a liposome model
  • It is suggested that for flavonoids, to be effective antimicrobials, interaction with the polar head-group of the model membrane followed by penetration into the hydrophobic regions must occur
  • The antimicrobial efficacies of the flavonoids were consistent with liposome interaction activities, kaempferol > hesperitin >-catechin hydrate > biochanin A
  • This study provides a liposome model capable of mimicking the cell membrane of E. coli ATCC 25922
  • The findings are important in understanding the antibacterial mechanism on cell membranes

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