Application of supercritical fluid to preparation of powders of high-molecular weight drugs for inhalation

The application of supercritical carbon dioxide to particle design has recently emerged as a promising way to produce powders of macromolecules such as proteins and genes

Hirokazu Okamoto

2007

Scholarcy highlights

  • The application of supercritical carbon dioxide to particle design has recently emerged as a promising way to produce powders of macromolecules such as proteins and genes
  • An insulin powder for inhalation was approved by authorities in Europe and the USA
  • In the 1990s proteins were precipitated with supercritical CO2 from solutions in an organic solvent such as dimethylsulfoxide, which caused significant unfolding of protein
  • Since 2000, aqueous solutions of proteins and genes have generally been used with a cosolvent such as ethanol to precipitate in CO2
  • This review is part of the Advanced Drug Delivery Reviews theme issue on “Drug Delivery Applications of Supercritical Fluid Technology”

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