Nanoantimicrobials

Bacterial, mycobacterial, and fungal infections represent an increasing worldwide threat

Josef JampĂ­lek

2017

Scholarcy highlights

  • Bacterial, mycobacterial, and fungal infections represent an increasing worldwide threat
  • The increase in the number of infections is caused by general immunosuppression, an increase in the number of HIV-positive patients, and development of resistance to commonly used drugs, and to second- or third-choice drugs
  • The development of cross-resistant or multidrug-resistant strains constitutes a serious problem as well. This situation can be solved by the discovery of new molecular scaffolds, reengineering/repositioning of some old drug classes, or application of nanotechnology, which may reduce the costs of design and discovery processes
  • Antimicrobial chemotherapeutics encapsulated in nanoformulations created from biodegradable polymers have great potential to replace the bulk form of these chemotherapeutics
  • Weaknesses in the application of nanoantimicrobials in clinical practice and potential health risks related to the application of nanoformulations are discussed

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