In a survival network for glioblastoma, we found that the epidermal growth factor receptor oncogene interacted with 46 genes
2015
Key concepts
- interaction network
- array comparative genomic hybridization
- tachykinin receptor 2
- Food and Drug Administration
- cytidine deaminase
- angiotensin receptor blockers
- Radiation hybrid mapping
- angiotensin converting enzyme
- Apolipoprotein B
- Caenorhabditis elegans
- arsenic trioxide
- Genetic networks
- Von Hippel-Lindau
- false discovery rate
- Venkatesan
- non-small cell lung cancer
- Cancer
- low density lipoprotein
- Alzheimer disease
- glioblastoma multiforme
- Drug repositioning
- radiation hybrid
- Thioredoxin reductase
- cysteinyl leukotriene receptor 2
- epidermal growth factor receptor
Scholarcy highlights
- New drug discovery is confronted by rising costs and diminishing success rates
- A survival network for glioblastoma multiforme at single gene resolution We explored the existence of survival networks in cancer
- We focus on the single gene resolution copy number alterations networks deduced from the radiation hybrid and glioblastoma datasets
- A total of 46 genes were identified that interacted with epidermal growth factor receptor in the combined glioblastoma/RH survival network, of which 10 happened to be targets for existing drugs
- SLC2A9 is a high capacity urate transporter and is inhibited by the uricosuric agent benzbromarone which is used to treat gout. These observations suggest that a flank attack strategy which strikes at both EGFR and its partner genes in the glioblastoma survival network may be an effective approach for treatment of these tumors
- An example of one such pathway in the RH survival network ends on the EGFR oncogene. A total of 22 genes interacted with the EGFR gene in the RH network, of which seven happened to be targets for existing compounds
- The strategy of copy number alterations network guided combinatorial therapy promises to be a useful approach to advancing novel treatments for a wide variety of common and uncommon disorders
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