Copy Number Networks to Guide Combinatorial Therapy of Cancer and Proliferative Disorders

In a survival network for glioblastoma, we found that the epidermal growth factor receptor oncogene interacted with 46 genes

Andy Lin; Desmond J. Smith

2015

copy number alterations networks and combinatorial therapy be targeted by directing approved drugs in single, double and triple combinations to interacting genes
A survival network for glioblastoma multiforme at single gene resolution We explored the existence of survival networks in cancer
We focus on the single gene resolution CNA networks deduced from the radiation hybrid and glioblastoma datasets
A total of 46 genes were identified that interacted with epidermal growth factor receptor in the combined glioblastoma/RH survival network, of which 10 happened to be targets for existing drugs
SLC2A9 is a high capacity urate transporter and is inhibited by the uricosuric agent benzbromarone which is used to treat gout. These observations suggest that a flank attack strategy which strikes at both EGFR and its partner genes in the glioblastoma survival network may be an effective approach for treatment of these tumors
There has been rising interest in inhibiting reduction/oxidation pathways for CNA networks and combinatorial therapy cancer treatment, since these pathways are required for cell proliferation
The strategy of copy number alterations network guided combinatorial therapy promises to be a useful approach to advancing novel treatments for a wide variety of common and uncommon disorders

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