Applications of Oligonucleotide Fingerprinting to the Identification of Viruses

This chapter focuses on applications of oligonucleotide fingerprinting to the identification of viruses

Olen M. Kew

2014

Scholarcy highlights

  • This chapter focuses on applications of oligonucleotide fingerprinting to the identification of viruses
  • Fingerprinting is a technique by which oligonucleotides, produced by cleavage of RNA molecules with specific ribonucleases, are separated in two dimensions. It is a definitive method of identifying RNA viruses according to their genotypes
  • Because all regions of the genome are represented by the large diagnostic oligonucleotides, a survey of the total genomic changes can be monitored
  • The evolutionary range of fingerprinting is short and relationships may not be evident for isolates of rapidly evolving viruses obtained over long intervals
  • These limitations are not large, compared to the full benefits offered to the virologist by the fingerprinting method

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