Immunohistochemical studies in mite antigen-induced patch test sites in atopic dermatitis

We investigated whether an eczematous reaction could be induced by patch testing with dust mite antigen

Yoichi Tanaka

2005

Scholarcy highlights

  • The role of mite allergen in atopic dermatitis is still unclear
  • We investigated whether an eczematous reaction could be induced by patch testing with dust mite antigen
  • We succeeded in reproducing an eczematous lesion and the mite-RAST-positive AD group showed a positive reaction much more than the RAST-negative group
  • It was observed that the mite antigens were trapped by some macrophages, which were apposed to lymphocytes
  • These results suggested that IgE-mediated contact hyper-sensitivity to mite antigen may develop and play an important role in AD

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