Motor nerve terminal loss from degenerating muscle fibers

These results argue that the maintenance of the full complement of nerve terminal branches at a neuromuscular junction is dependent on the presence of a healthy muscle fiber

Mark Rich

2004

Scholarcy highlights

  • The fate of nerve terminals following elimination of postsynaptic target cells was studied in living mouse muscle
  • Several days after muscle fiber damage, observations of previously identified neuromuscular junctions showed that motor nerve terminal branches had rapidly disappeared from degenerating muscle fibers
  • The distribution of acetylcholine receptors reorganized in the regenerated muscle so that perfect alignment was reestablished with the newly configured nerve terminals
  • These results argue that the maintenance of the full complement of nerve terminal branches at a neuromuscular junction is dependent on the presence of a healthy muscle fiber
  • Regenerating muscle is dependent on the nerve terminal for the organization and maintenance of postsynaptic receptors
  • We recommend that commenters identify themselves with full names and affiliations

Need more features? Save interactive summary cards to your Scholarcy Library.