Testicular toxicity of boric acid (BA): Relationship of dose to lesion development and recovery in the F344 rat

The present study addressed whether inhibited spermiation can be separated from atrophy based on dose, compared testis boron dosimetry to lesion development, determined how inhibited spermiation was reflected by common reproductive endpoints, and examined reversibility of the testicular lesions

Warren W. Ku; Robert E. Chapin; Robert N. Wine; Beth C. Gladen

2002

Scholarcy highlights

  • High-dose boric acid produces testicular lesions in adult rats, characterized by inhibited spermiation followed by atrophy
  • The present study addressed whether inhibited spermiation can be separated from atrophy based on dose, compared testis boron dosimetry to lesion development, determined how inhibited spermiation was reflected by common reproductive endpoints, and examined reversibility of the testicular lesions
  • Inhibited spermiation could be separated from atrophy based on dose, with each lesion aspect expressed at different threshold testis B concentrations with no B accumulation during the 9-week exposure
  • These data suggest that separate mechanisms may be operating for these lesion aspects based on testis B concentration and that B dose rate was important for testicular toxicity
  • The ability to separate inhibited spermiation from atrophy based on dose and testis B dosimetry will be useful in evaluating possible mechanisms
  • The presence of dividing spermatogonia during long-term BA-induced atrophy suggests that this model should be useful for identifying critical components involved in the reinitiation of spermatogenesis

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