Role of metals in oxygen radical reactions

Partially-reduced forms of dioxygen or “oxy-radicals” and oxidants of comparable reactivity are implicated in an increasing number of physiological, toxicological, and pathological states

Steven D. Aust; Lee A. Morehouse; Craig E. Thomas

2003

Scholarcy highlights

  • Partially-reduced forms of dioxygen or “oxy-radicals” and oxidants of comparable reactivity are implicated in an increasing number of physiological, toxicological, and pathological states
  • Transition metal catalysis is recognized as being integral to the generation and the reactions of these activated oxygen species
  • Factors such as pH and chelation govern the reactivity of the transition metals with dioxygen and “oxy-radicals” and influence the apparent mechanisms by which oxidative damage to phospholipids, DNA, and other biomolecules is initiated
  • Under certain conditions metal storage and transport proteins may furnish additional redox active metals

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