Antiglaucomatous activity of betaxolol chlorhydrate sorbed onto different isobutylcyanoacrylate nanoparticle preparations
The objectives of the present work were to evaluate the effects, on the reduction of the intra-ocular pressure in glaucomatous rabbits, of different physico-chemical parameters such as: the adsorption percentage of an antiglaucomatous drug onto isobutylcyanoacrylate nanoparticles; the binding type of the drug onto the surface of the particles
The objectives of the present work were to evaluate the effects, on the reduction of the intra-ocular pressure in glaucomatous rabbits, of different physico-chemical parameters such as: the adsorption percentage of an antiglaucomatous drug onto isobutylcyanoacrylate nanoparticles; the binding type of the drug onto the surface of the particles
The suspension with the lowest drug payload did not significantly increase the maximal intensity of the therapeutic response and tended to prolong the reduction of the IOP in time
Part of this work has been presented at the 15th Controlled Release Society Meeting, August 1988, Basel, Switzerland
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