Antiglaucomatous activity of betaxolol chlorhydrate sorbed onto different isobutylcyanoacrylate nanoparticle preparations

The objectives of the present work were to evaluate the effects, on the reduction of the intra-ocular pressure in glaucomatous rabbits, of different physico-chemical parameters such as: the adsorption percentage of an antiglaucomatous drug onto isobutylcyanoacrylate nanoparticles; the binding type of the drug onto the surface of the particles

L. Marchal-Heussler

2002

Scholarcy highlights

  • The objectives of the present work were to evaluate the effects, on the reduction of the intra-ocular pressure in glaucomatous rabbits, of different physico-chemical parameters such as: the adsorption percentage of an antiglaucomatous drug onto isobutylcyanoacrylate nanoparticles; the binding type of the drug onto the surface of the particles
  • The suspension with the lowest drug payload did not significantly increase the maximal intensity of the therapeutic response and tended to prolong the reduction of the IOP in time
  • Part of this work has been presented at the 15th Controlled Release Society Meeting, August 1988, Basel, Switzerland

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