Production of superoxide anions and hydrogen peroxide in Ehrlich ascites tumour cell nuclei

Nuclei isolated from Ehrlich-Lettré ascites tumour cells catalyze the co-oxidation of epinphrine to adrenochrome in the presence of NADPH

G.M. Bartoli; T. Galeotti; A. Azzi

2003

Scholarcy highlights

  • Nuclei isolated from Ehrlich-Lettré ascites tumour cells catalyze the co-oxidation of epinphrine to adrenochrome in the presence of NADPH
  • Measurements of superoxide dismutase activity indicate the presence of this enzyme in the ascites cell nuclei, the sensitivity of adrenochrome formation to externally added superoxide dismutase indicates that the endogenous enzyme is not sufficient for a complete protection from superoxide radicals

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