The effect of transfection of the CEA gene on the metastatic behavior of the human colorectal cancer cell line MIP-101

This study provides further evidence for the involvement of Carcinoembryonic antigen in the metastatic process

Peter Thomas; Aniruddha Gangopadhyay; Glenn Steele; Charles Andrews; Hiroshi Nakazato; Shinzo Oikawa; J.Milburn Jessup

2002

Scholarcy highlights

  • Carcinoembryonic antigen has been shown to increase the metastatic potential of some human colorectal cancer cell lines
  • To investigate further the mechanisms involved we have produced three clones from the poorly differentiated human colorectal cancer cell line MIP-101 that have been transfected with the full length cDNA encoding for human carcinoembryonic antigen
  • Immunohistopathology of the hepatic tumors showed strong CEA staining from clones 6 and 17 with weak staining from clone 8
  • The parent cell line was negative for CEA as were the neo-transfected controls
  • We observed strong CEA staining in Kupffer cells in the normal liver adjacent to the CEA producing tumors
  • This study provides further evidence for the involvement of CEA in the metastatic process
  • This study provides further evidence for the involvement of Carcinoembryonic antigen in the metastatic process

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