Antioxidant behaviour of caffeine: Efficient scavenging of hydroxyl radicals

This study reports on the reaction of 1,3,7-trimethylxanthine with the hydroxyl radical, as investigated by electron spin resonance spin trapping

X. Shi

2002

Scholarcy highlights

  • Considerable controversy exists in the literature regarding the toxicity of coffee, including its possible carcinogenic and anticarcinogenic properties
  • This study reports on the reaction of 1,3,7-trimethylxanthine with the hydroxyl radical, as investigated by electron spin resonance spin trapping
  • The ·OH was generated by the Fenton reaction as well as by the reaction of chromium(V) with H2O2
  • The results show that caffeine effectively scavenges ·OH with a reaction rate constant of ∼ 5.9 × 109m−1 sec−1 that is comparable with those of other efficient ·OH radical scavengers
  • ESR measurements provide evidence that a caffeine-derived oxygen-centred radical is formed in the reaction of caffeine with ·OH and suggest a biochemical basis for the understanding of the reported anticarcinogenic properties of caffeine and related methylxanthine compounds

Need more features? Save interactive summary cards to your Scholarcy Library.