This study reports on the reaction of 1,3,7-trimethylxanthine with the hydroxyl radical, as investigated by electron spin resonance spin trapping
2002
Key concepts
Scholarcy highlights
- Considerable controversy exists in the literature regarding the toxicity of coffee, including its possible carcinogenic and anticarcinogenic properties
- This study reports on the reaction of 1,3,7-trimethylxanthine with the hydroxyl radical, as investigated by electron spin resonance spin trapping
- The ·OH was generated by the Fenton reaction as well as by the reaction of chromium(V) with H2O2
- The results show that caffeine effectively scavenges ·OH with a reaction rate constant of ∼ 5.9 × 109m−1 sec−1 that is comparable with those of other efficient ·OH radical scavengers
- ESR measurements provide evidence that a caffeine-derived oxygen-centred radical is formed in the reaction of caffeine with ·OH and suggest a biochemical basis for the understanding of the reported anticarcinogenic properties of caffeine and related methylxanthine compounds
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