Cognitive function in major depression

Forty patients with a major depressive episode were divided into equal endogenous and neurotic sub-groups using the Newcastle scale. They were all rated on the 17-item Hamilton scale and with a variety of neuropsychological tests

M.-P. Austin; M. Ross; C. Murray; R.E. O'Caƕroll; K.P. Ebmeier; G.M. Goodwin

2002

Scholarcy highlights

  • Forty patients with a major depressive episode were divided into equal endogenous and neurotic sub-groups using the Newcastle scale. They were all rated on the 17-item Hamilton scale and with a variety of neuropsychological tests
  • They were compared with 20 age- and education-matched control subjects
  • The endogenous group was more impaired on digit symbol substitution and the Trail making Test
  • Impairment was correlated with symptom scores on the Hamilton and Newcastle scales, even after allowing for the effect of age
  • It is concluded that the conventional distinction between organic and functional impairment breaks down in severe depressive illness
  • The implications of this for clinical neuropsychological testing and the anatomy of the brain dysfunction in depressive illness are discussed

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