Molecular characterization of receptors for human interleukin-8, GRO/melanoma growth-stimulatory activity and neutrophil activating peptide-2

Interleukin-8, neutrophil activating peptide-2, and growth regulated gene are members of a family of peptides which are chemotactic agents for inflammatory cells such as neutrophils

Douglas Pat Cerretti; Carl J. Kozlosky; Tim Vanden Bos; Nicole Nelson; David P. Gearing; M.Patricia Beckmann

2002

Scholarcy highlights

  • Interleukin-8, neutrophil activating peptide-2, and growth regulated gene are members of a family of peptides which are chemotactic agents for inflammatory cells such as neutrophils
  • Receptors have been identified for IL-8, GRO and NAP-2 on human neutrophils and granulocytic cell lines, and it has been observed that these cytokines can cross-compete for binding to a common receptor
  • The type 1 receptor binds only IL-8 while the type 2 receptor binds IL-8, GRO and NAP-2 at high affinity when respective cDNAs are expressed in COS-7 cells
  • These receptors show significant homology with receptors for other chemotactic agents and with potential coding regions from the human cytomegalovirus genome

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