Biodegradable polymers

We report on the development of an injectable, biodegradable, thermosensitive and superparamagnetic iron oxide nanoparticle-loaded nanocapsule hydrogels system for multiple Magnetic hyperthermia therapy and long-term magnetic resonance imaging contrast

Jan H.L. Crommen

2003

Scholarcy highlights

  • Polyphosphazenes with hydrolytic labile substituents have potential as biodegradable materials
  • The main hydrolysis pathway of poly devices In vitro involves release of the amino acid ester side-group followed by hydrolysis of the ester with formation of the amino acid and ethanol
  • Poly(organophosphazene) hydrogels, as an injectable, biodegradable, amphiphilic and thermosensitive system, have been synthesized, characterized and exploited for various biomedical applications in our previous reports, such as sustained release of chemical drug, protein, gene and long-term diagnosis.The degradable products of PPZ hydrogels via carboxylic acid-catalyzed degradation, such as amino acids, ethanol, phosphate, and ammonia, have been proved to be non-toxic and biocompatible.For the present study, we synthesized SPION-loaded nanocapsule hydrogels for multiple Magnetic hyperthermia therapy, which was assembled via hydrophobic interaction between SPIONs and PPZ hydrogels
  • We report on the development of an injectable, biodegradable, thermosensitive and superparamagnetic iron oxide nanoparticle-loaded nanocapsule hydrogels system for multiple MHT and long-term magnetic resonance imaging contrast
  • More than three weeks retention of SPIONs within tumors after a single injection of SPION-NHs facilitated successful multiple MHT, which was monitored by T2-weighted MRI
  • Excellent in vivo anti-cancer effect was observed after four cycles of MHT without severe damage on the surrounding healthy tissues, which was in contrast to single magnetic thermal ablation
  • This new model allows the results from mesoscale simulations to be incorporated into micro- or macro-scale computational fluid dynamics transport simulations of protein adsorption in practical devices

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