Evaluation of plasma polymerized hexamethylcyclotrisiloxane biomaterials towards adhesion of canine platelets and leucocytes

We report data from the literature and our laboratory dealing with interactions between antigen-presenting cells and phosphatidylserine-expressing cell dusts, including apoptotic leukocytes and blood cell-derived microparticles

Attar S. Chawla

2003

Scholarcy highlights

  • Silicons coated CelgardĀ®-2400 and SilasticĀ® membranes were prepared by plasma polymerization of hexamethylcyclotrisiloxane
  • The adhesion of canine platelets and leucocytes was tested by passing whole blood from the anaesthetized mongrel dog in an ex-vivo shunt system
  • We report data from the literature and our laboratory dealing with interactions between antigen-presenting cells and phosphatidylserine-expressing cell dusts, including apoptotic leukocytes and blood cell-derived microparticles
  • We show that Coronary heart disease was associated with changes in the transport of circulating miRNA, decreased miRNA enrichment in microparticles
  • We report on MP changes in thawed plasma between its initial thaw and five days of storage
  • Decline in MP with storage contributes to FFP-5's reduced ability to provide the hemostatic potential exhibited by FFP-0, suggesting the presence of platelet MPs in freshly thawed plasma may be beneficial and protective in the initial treatment of hemorrhage

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