We have generated H-2b mice with a homozygous null mutation in the granzyme B gene
2004
Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells
Key concepts
Scholarcy highlights
- We have generated H-2b mice with a homozygous null mutation in the granzyme B gene
- Gzm B−/− cytotoxic T lymphocytes have a profound defect in their ability to induce rapid DNA fragmentation and apoptosis in allogeneic target cells
- This defect is kinetic since DNA fragmentation is partially compensated and 51Cr release is completely resuced with long incubation times
- We conclude that gzm B serves a critical and nonredundant role for the rapid induction of target cell DNA fragmentation and apoptosis by alloreactive cytotoxic T lymphocytes
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