bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

Death is the fate of most developing T lymphocytes

Andreas Strasser

2004

Scholarcy highlights

  • Death is the fate of most developing T lymphocytes
  • No T cells reactive with self-superantigens appeared in the lymph nodes, but an excess was found in the thymus
  • These observations, together with previous findings on B cells, suggest that modulated bcl-2 expression is a determinant of life and death in normal lymphocytes
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