T cell tolerance by clonal elimination in the thymus

In this paper we show that T cells expressing Vβ17a are selectively eliminated from the peripheral T cell and mature thymocyte pool of mice expressing IE, but are present in expected numbers in the immature thymocyte population of such animals

John W. Kappler

2004

Scholarcy highlights

  • The monoclonal antibody KJ23a reacts with T cell receptors utilizing the Vβ segment Vβ17a
  • T cells bearing Vβ17a + receptors react with very high frequency with the MHC class II protein, IE
  • In this paper we show that T cells expressing Vβ17a are selectively eliminated from the peripheral T cell and mature thymocyte pool of mice expressing IE, but are present in expected numbers in the immature thymocyte population of such animals
  • These results show that in normal animals tolerance to self-MHC is due to clonal elimination rather than suppression
  • They indicate that tolerance induction may occur in the thymus at the time immature thymocytes are selected to move into the mature thymocyte pool
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