Strain, stress, neurodegeneration and longevity

Laboratory studies indicate that the life-span of inbred rodent strains is inversely related to the intensity of their behavioral and neuroendocrine responses to stressful stimuli

Gad M Gilad; Varda H Gilad

2002

Scholarcy highlights

  • Laboratory studies indicate that the life-span of inbred rodent strains is inversely related to the intensity of their behavioral and neuroendocrine responses to stressful stimuli
  • A shorter life-span is associated with accelerated age-dependent degenerative changes in specific stress-responsive neuronal systems
  • It is proposed that inherent hyper-reactivity to stressors is genetically linked to a shorter life-span and to accelerated age-dependent neurodegeneration
  • Several experimental approaches to test ‘this stress-longevity-neurodegeneration linkage hypothesis’ are outlined

Need more features? Save interactive summary cards to your Scholarcy Library.