Huperzine A as a pretreatment candidate drug against nerve agent toxicity

Huperzine A is a naturally-occuring, potent, reversible inhibitor of acetylcholinesterase that crosses the blood-brain barrier

Jacob Grunwald

2002

Scholarcy highlights

  • Huperzine A is a naturally-occuring, potent, reversible inhibitor of acetylcholinesterase that crosses the blood-brain barrier
  • To examine its ability to protect against nerve agent poisoning, HUP was administered i.p. to mice, and the s.c
  • LD50 of soman was determined at various time intervals after pretreatment
  • The long-lasting antidotal efficacy displayed by HUP correlated with the time course of the blood-AChE inhibition
  • The results suggest that the protection of animals by HUP from soman poisoning was achieved by temporarily sequestering the active site region of the physiologically important AChE

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