Diffusion effects in the metabolism of hydrogen peroxide by rat liver peroxisomes

Rat liver peroxisomes are membrane-bounded organelles containing catalase and oxidases producing H2O2

Brian Poole

2004

Scholarcy highlights

  • Rat liver peroxisomes are membrane-bounded organelles containing catalase and oxidases producing H2O2
  • Diffusion effects in the metabolism of H2O2 and the physiological significance of the structure of peroxisomes are explored on the basis of two models
  • On the basis of previously published experimental data and model II, it is concluded that the latency of catalase activity in intact peroxisomes is due to a permeability barrier to H2O2 at the peroxisomal membrane rather than to a restriction of H2O2 diffusion within the peroxisomes
  • Peroxisomes are calculated to be very efficient at destroying the H2O2 produced within them, whether the H2O2 is produced in the catalase-free core or in the catalase-containing matrix
  • The efficiency of H2O2 trapping is the consequence of the membrane permeability barrier
  • Less than 2% of the H2O2 produced in peroxisomes leaves the particles
  • A similar H2O2 trapping efficiency could be achieved by particles without a membrane barrier only if H2O2 diffusion within such particles were reduced by many orders of magnitude
  • Supported by grants GB-5796X and GB-35258X from the National Science Foundation

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