Effects of vinblastine and colchicine on neural regulation of the fast and slow skeletal muscles of the rat

The chronic application of vinblastine or colchicine to the nerves supplying the extensor and soleus muscles of the rat caused the development of various signs of denervation without affecting muscle activity per se

E.X. Albuquerque

2004

Scholarcy highlights

  • The chronic application of vinblastine or colchicine to the nerves supplying the extensor and soleus muscles of the rat caused the development of various signs of denervation without affecting muscle activity per se
  • The resting membrane potential of the surface fibers of both muscles was lower than control 5 days after the application of either drug, and after 7 days' exposure of the sciatic nerve to vinblastine, fibers of the extensor and soleus muscles were depolarized by about 13 mv
  • The resting membrane potentials of both muscles declined from a control value of −75 mv to about −62 mv after 7 days
  • Elicited action potentials and the resultant muscle activity, which were similar to control, were present in each fiber during the development of membrane depolarization, extrajunctional ACh sensitivity, and tetrodotoxin-resistant action potentials
  • The temporal sequence of alterations produced by chronic application of vinblastine or colchicine to the nerves supplying these muscles is the following: an increase or negligible change in miniature end-plate potential frequency; partial membrane depolarization; appearance of extrajunctional ACh sensitivity; appearance of tetrodotoxin-resistant action potentials
  • Dr Sansone's address is the Department of Anatomy, Schools of Medicine and Dentistry, State University of New York at Buffalo, NY 14214

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