The intracellular distribution and function of the high mobility group chromosomal proteins

This brief review provides a framework for discussing current approaches being used to determine the cellular localization and function of the high mobility group chromosomal proteins

L EINCK

2004

Scholarcy highlights

  • This brief review provides a framework for discussing current approaches being used to determine the cellular localization and function of the high mobility group chromosomal proteins
  • The evolutionary conservation in the primary and tertiary structure as well as the observed correlations between cell phenotype and quantitative changes in protein levels and in post-synthesis modifications suggests that these proteins are components obligatory for proper cellular function
  • Proteins HMG 1, 2 are DNA-binding proteins which can distinguish between various types of single-stranded regions of the genome
  • The data available presently suggests that these proteins are important structural elements of chromatin and chromosomes

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