Enhancement of azo dye carcinogenesis by dietary sodium sulphate

Male Sprague-Dawley rats were fed diets containing 0·06% 3′methyl-4-dimethylaminoazobenzene, 0·06% 3′MeDAB plus 0·84% Na2SO4 and 0·06% 3′MeDAB plus 0·8% acetanilide; further groups were fed a control diet and diets containing either 0·84% Na2SO4 or 0·8% acetanilide

Jill M. Blunck

2004

Scholarcy highlights

  • Male Sprague-Dawley rats were fed diets containing 0·06% 3′methyl-4-dimethylaminoazobenzene, 0·06% 3′MeDAB plus 0·84% Na2SO4 and 0·06% 3′MeDAB plus 0·8% acetanilide; further groups were fed a control diet and diets containing either 0·84% Na2SO4 or 0·8% acetanilide
  • Addition of Na2SO4 to the 3′MeDAB diet increased the probability of developing liver tumours 1 cm or more in diameter, multiple tumours, and metastic spread
  • These increases seemed to be a result of a shorter latent period rather than an increase either in the rate of tumour development or in the number of transformed foci per liver
  • Addition of acetanilide to the 3′MeDAB diet completely inhibited tumour induction and prevented the development of cirrhosis and hyperplastic changes in the liver which have been regarded as preneoplastic

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