Morphogenetic interactions in the development of the mouse thymus gland

Neither component can develop in isolation, in vitro or in vivo, but clustering of the two tissues leads to the restoration of the morphogenetic system, with resultant in vitro lobulation and the in vivo formation of lymphoidal tissue. 4

Robert Auerbach

2004

Key concepts

Scholarcy highlights

  • Neither component can develop in isolation, in vitro or in vivo, but clustering of the two tissues leads to the restoration of the morphogenetic system, with resultant in vitro lobulation and the in vivo formation of lymphoidal tissue. 4
  • Mesenchyme from a variety of embryonic rudiments can exert a morphogenetic effect in vitro, the specific pattern of the epithelial response varying with the source of mesenchyme used
  • The mesenchymal influence can be exerted across a 20 μ millipore filter barrier
  • Supported in part by research grant C-3985 from the National Institutes of Health, and by an institutional grant from the American Cancer Society

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