Psychophysiological correlates of posttraumatic stress disorder in Vietnam veterans

We found a significant group × intensity interaction for P2 peak amplitude at CZ

Stephen R. Paige; Graham M. Reid; Mary Gwyn Allen; Joseph E.O. Newton

2003

Scholarcy highlights

  • We measured event-related brain potential component amplitudes and heart rate to four intensities of randomly presented tones in two matched groups of drug-free male Vietnam veterans: 12 patients diagnosed with posttraumatic stress disorder and 6 normal combat veterans
  • Subjects were evaluated with structured diagnostic interviews and anxiety and depression rating scales
  • We found a significant group × intensity interaction for P2 peak amplitude at CZ
  • Subjects were classified as augmenters or reducers: positive P2 slopes as a function of stimulus intensity implying augmentation and negative slopes implying reduction
  • HR change scores were significantly responsive to the manipulation of stimulus intensity and to the difference between our two groups
  • P2 reduction differentiates Vietnam veterans with combat-related posttraumatic stress disorder from combat veteran controls, and PTSD subjects are more autonomically arousable than their combat veteran peers

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