Cellular mixed disulphides between thiols and proteins, and their possible implication for radiation protection

The occurrence of mixed disulphides between thiols and proteins has been demonstrated in crystalline bovine serum albumin and in proteins of Ehrlich ascites tumour cells

H. Modig

2002

Scholarcy highlights

  • The occurrence of mixed disulphides between thiols and proteins has been demonstrated in crystalline bovine serum albumin and in proteins of Ehrlich ascites tumour cells
  • The thiols could be released from the proteins by reduction of the disulphide bonds with sodium borohydride
  • It is suggested that protein bound glutathione may represent a reservoir of physiological radiation protector
  • The release of glutathione from cellular proteins by an exchange reaction may be of significance or the radio protective action of cysteamine

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