“Thymineless” death in androgen-independent prostatic cancer cells

The molecular mechanism of “thymineless” death induced by 5-fluoro-deoxyuridine or trifluorothymidine, in androgen-independent rat prostatic adenocarcinoma AT-3 cells was investigated

Natasha Kyprianou

2004

Key concepts

Scholarcy highlights

  • The molecular mechanism of “thymineless” death induced by 5-fluoro-deoxyuridine or trifluorothymidine, in androgen-independent rat prostatic adenocarcinoma AT-3 cells was investigated
  • Killing of AT-3 cells by osmotic lysis, or membrane-targeted metabolic inhibitors results in neither the stereotypic DNA fragmentation into nucleosomal oligomers nor the elevation of TRPM-2 mRNA levels but to non-specific biochemical changes characteristic of necrosis. These results suggest that androgen-independent prostatic cancer cells retain a major portion of the programmed cell death cascade which can be activated by non-androgen ablative cytotoxic drugs that induce “thymineless” death

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