Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

Staurosporine, microbial alkaloid which has been known to have anti-fungal activity was found to inhibit markedly phospholipidCa++dependent protein kinase from rat brain, with an IC50 value of 2.7 nM

Tatsuya Tamaoki

2004

Key concepts

Scholarcy highlights

  • Staurosporine, microbial alkaloid which has been known to have anti-fungal activity was found to inhibit markedly phospholipidCa++dependent protein kinase from rat brain, with an IC50 value of 2.7 nM
  • The inhibition of protein kinase C was not competitive with phospholipid
  • This compound showed the strong cytotoxic effect on the growth of HeLa S3 cells, with an IC50 value of 4 × 10−12M under the condition of 72 hr-exposure

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