Changes in phosphatidylcholine liposomes caused by a mixture of Triton X-100 and sodium dodecyl sulfate

The mechanisms governing the interaction of equimolecular mixtures of Triton X-100 and sodium dodecyl sulfate with phosphatidylcholine liposomes were investigated

Alfonso de la Maza

2002

Scholarcy highlights

  • The mechanisms governing the interaction of equimolecular mixtures of Triton X-100 and sodium dodecyl sulfate with phosphatidylcholine liposomes were investigated
  • Permeability alterations were determined as a change in 5(6)-carboxyfluorescein released from the interior of vesicles and bilayer solubilization as a decrease in the static light-scattered by liposome suspensions
  • A maximum bilayer/water partitioning of surfactant mixture was reached at 30% CF release, which correlated with the increased presence of SDS in the bilayers
  • These findings may be correlated with the reduced deleterious effects caused by this mixture in different tissues versus pure SDS, given that the presence of TX-100 may modilate the level of SDS partitioning in the human stratum corneum
  • Re effective surfactant/lipid molar ratio effective sirfactant/lipid molar ratio for bilayer saturation effective surfactant/lipid molar ratio for bilayer solubilization surfactant concentration in the aqueous medium for the mixture Tx-100/sodium dodecyl sulfate

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