Poly(ethylene glycol) on the liposome surface: on the mechanism of polymer-coated liposome longevity

The hypothetical model is built explaining the molecular mechanism of protective action of poly(ethylene glycol) on liposomes in vivo

Vladimir P. Torchilin

2003

Scholarcy highlights

  • The hypothetical model is built explaining the molecular mechanism of protective action of poly(ethylene glycol) on liposomes in vivo
  • The protective layer of the polymer on the liposome surface is considered as a statistical ‘cloud’ of polymer possible conformations in solution
  • Experiments have been performed with the quenching of liposome-associated fluorescent label with protein from solution
  • Highly-reactive and low-reactive populations of chemically identical reactive sites have been found on polymer-coated liposomes
  • Experimental data satisfactory confirm the suggested mechanism for the longevity of polymer-modified liposome

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