The oxygen dependence of cellular energy metabolism

Suspensions of cultured C 1300 neuroblastoma cells, sarcoma 180 ascites tumor cells, and Tetrahymena pyriformis cells were used to study the oxygen dependence of cellular energy metabolism

David F. Wilson; Maria Erecińska; Charles Drown; Ian A. Silver

2005

Scholarcy highlights

  • Suspensions of cultured C 1300 neuroblastoma cells, sarcoma 180 ascites tumor cells, and Tetrahymena pyriformis cells were used to study the oxygen dependence of cellular energy metabolism
  • Cellular respiration was found to be almost independent of oxygen tension to values of less than 20 μm with an apparent Km for oxygen of less than 1 μm
  • The reduction of mitochondrial cytochrome c was found to be dependent on oxygen tension at all values from 240 μm downward
  • The respiratory rate is maintained constant when the oxygen tension is lowered by decreasing values of the cytosolic and intramitochondrial because these regulatory parameters adjust to maintain a constant rate of ATP synthesis
  • The lack of oxygen dependence in the respiratory rate means that the rate of cellular ATP utilization is essentially oxygen independent until the mitochondria can no longer synthesize ATP at the required rate and
  • M.E. is an established investigator for the American Heart Association

Need more features? Save interactive summary cards to your Scholarcy Library.