Inhibition of electron and energy transfer in mitochondria by 19-nor-ethynyltestosterone acetate

19-Nor-ethynyltestosterone acetate is an effective inhibitor of mitochondrial respiration in the vicinity of the NADH dehydrogenase flavoprotein

A. Boveris

2004

Scholarcy highlights

  • 19-Nor-ethynyltestosterone acetate is an effective inhibitor of mitochondrial respiration in the vicinity of the NADH dehydrogenase flavoprotein
  • Half-maximal inhibitory values allow the establishment of NEA as a more potent inhibitor than barbiturates and guanidines but less effective than piericidin and rotenone
  • Addition of NEA to mitochondria respiring NAD-linked substrates shifts the redox level of pyridine nucleotide toward the reduced state while the reverse occurs with cytochrome b and ubiquinone
  • The effect of NEA on absorbancy levels at the flavo-protein spectral region, with both mitochondrial and submitochondrial preparations, can be explained in terms of interaction of NEA with a steroid-sensitive site located on the oxygen side of the mitochondrial NADH flavoprotein, very close or partly superimposed upon the rotenone site
  • Aided by grants from Consejo Nacional de Investigaciones Científicas y Técnicas, The Jane Coffin Childs Fund for Medical Research, and the United States Air Force Office under Grant AFOSR-68-1395, monitored by the Air Force Office of Scientific Research, Office of Aerospace Research

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