Congestive heart failure and left ventricular dysfunction complicating doxorubicin therapy
To impact on the development of clinical congestive heart failure as a complication of doxorubicin therapy, left ventricular ejection fraction was monitored with serial resting radionuclide angiocardiography in 1,487 patients with cancer over a seven-year period in both university and community hospital environments
Ronald G. Schwartz
2004
Scholarcy highlights
To impact on the development of clinical congestive heart failure as a complication of doxorubicin therapy, left ventricular ejection fraction was monitored with serial resting radionuclide angiocardiography in 1,487 patients with cancer over a seven-year period in both university and community hospital environments
Clinical congestive heart failure improved in 87 percent given routine therapy with digitalis, diuretics, and/or vasodilators
The occurrence of clinical congestive heart failure was compared in those patients whose management was concordant with proposed criteria and in those whose management was not
Group A had a lower incidence of congestive heart failure compared with Group B and had only mild congestive heart failure that resolved with treatment and no deaths due to congestive heart failure
The incidence, persistence, late development, predictability, and reversibility of clinical congestive heart failure were comparable in university and community hospital settings
It is concluded that in doxorubicin -treated patients at high risk for congestive heart failure , monitoring resting left ventricular function with radionuclide angiocardiography is associated with a low incidence, benign course, and reversible degree of doxorubicin -induced congestive heart failure ; adherence to appropriate guidelines reduces the incidence and severity of clinical congestive heart failure ; serial resting radionuclide angiocardiography reliably monitors cardiotoxicity and identifies patients who safely tolerate high cumulative doses of doxorubicin
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